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Multi-omic approach identifies hypoxic tumor-associated myeloid cells that drive immunobiology of high-risk pediatric ependymoma

Summary: Ependymoma (EPN) is a devastating childhood brain tumor. Single-cell analyses have illustrated the cellular heterogeneity of EPN tumors, identifying multiple neoplastic cell states including a mesenchymal-differentiated subpopulation which characterizes the PFA1 subtype. Here, we characteri...

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Furkejuvvon:
Váldodahkkit: Andrea M. Griesinger, Kent Riemondy, Nithyashri Eswaran, Andrew M. Donson, Nicholas Willard, Eric W. Prince, Simon M.L. Paine, Georgia Bowes, John Rheaume, Rebecca J. Chapman, Judith Ramage, Andrew Jackson, Richard G. Grundy, Nicholas K. Foreman, Timothy A. Ritzmann
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Elsevier 2023-09-01
Ráidu:iScience
Fáttát:
Microenvironment
Biopsy sample
Components of the immune system
Proteomics
Transcriptomics
Liŋkkat:http://www.sciencedirect.com/science/article/pii/S2589004223016620
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