Redox-Mediated Inactivation of the Transcriptional Repressor RcrR is Responsible for Uropathogenic Escherichia coli’s Increased Resistance to Reactive Chlorine Species

ABSTRACT The ability to overcome stressful environments is critical for pathogen survival in the host. One challenge for bacteria is the exposure to reactive chlorine species (RCS), which are generated by innate immune cells as a critical part of the oxidative burst. Hypochlorous acid (HOCl) is the...

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Bibliografische Detailangaben

Hauptverfasser:	Sadia Sultana, Mary E. Crompton, Kennadi Meurer, Olivia Jankiewicz, Grace H. Morales, Colton Johnson, Elise Horbach, Kevin Pierre Hoffmann, Pooja Kr, Ritika Shah, Greg M. Anderson, Nathan T. Mortimer, Jonathan E. Schmitz, Maria Hadjifrangiskou, Alessandro Foti, Jan-Ulrik Dahl
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2022-10-01
Schriftenreihe:	mBio
Schlagworte:	bacterial defense systems hypochlorous acid oxidative stress reactive chlorine species transcriptional regulation
Online-Zugang:	https://journals.asm.org/doi/10.1128/mbio.01926-22
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