Redox-Mediated Inactivation of the Transcriptional Repressor RcrR is Responsible for Uropathogenic Escherichia coli’s Increased Resistance to Reactive Chlorine Species

ABSTRACT The ability to overcome stressful environments is critical for pathogen survival in the host. One challenge for bacteria is the exposure to reactive chlorine species (RCS), which are generated by innate immune cells as a critical part of the oxidative burst. Hypochlorous acid (HOCl) is the...

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Autors principals:	Sadia Sultana, Mary E. Crompton, Kennadi Meurer, Olivia Jankiewicz, Grace H. Morales, Colton Johnson, Elise Horbach, Kevin Pierre Hoffmann, Pooja Kr, Ritika Shah, Greg M. Anderson, Nathan T. Mortimer, Jonathan E. Schmitz, Maria Hadjifrangiskou, Alessandro Foti, Jan-Ulrik Dahl
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2022-10-01
Col·lecció:	mBio
Matèries:	bacterial defense systems hypochlorous acid oxidative stress reactive chlorine species transcriptional regulation
Accés en línia:	https://journals.asm.org/doi/10.1128/mbio.01926-22
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