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Altered expression of 3α-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes

3α-Hydroxysteroid dehydrogenase (3α-HSD) isoforms (AKR1C1–AKR1C4) are aldo-keto reductases that metabolize steroids and other substances in many tissues including the CNS. Here we demonstrated that in glaucomatous human optic nerve heads, increased expression of 3α-HSD was localized to reactive astr...

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Hlavní autoři: O.A Agapova, P Yang, W-H Wang, D.A Lane, A.F Clark, B.I Weinstein, M.R Hernandez
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2003-10-01
Edice:Neurobiology of Disease
Témata:
Optic nerve head astrocytes
Glaucoma
Optic nerve transection
3α-HSD
Neurosteroid
AKR1C1
On-line přístup:http://www.sciencedirect.com/science/article/pii/S0969996103001013
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