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Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma

Abstract Leukemic cutaneous T‐cell lymphomas (L‐CTCL) are lymphoproliferative disorders of skin‐homing mature T‐cells causing severe symptoms and high mortality through chronic inflammation, tissue destruction, and serious infections. Despite numerous genomic sequencing efforts, recurrent driver mut...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Helena Sorger, Saptaswa Dey, Pablo Augusto Vieyra‐Garcia, Daniel Pölöske, Andrea R Teufelberger, Elvin D de Araujo, Abootaleb Sedighi, Ricarda Graf, Benjamin Spiegl, Isaac Lazzeri, Till Braun, Ines Garces de los Fayos Alonso, Michaela Schlederer, Gerald Timelthaler, Petra Kodajova, Christine Pirker, Marta Surbek, Michael Machtinger, Thomas Graier, Isabella Perchthaler, Yi Pan, Regina Fink‐Puches, Lorenzo Cerroni, Jennifer Ober, Moritz Otte, Jana D Albrecht, Gary Tin, Ayah Abdeldayem, Pimyupa Manaswiyoungkul, Olasunkanmi O Olaoye, Martin L Metzelder, Anna Orlova, Walter Berger, Marion Wobser, Jan P Nicolay, Fiona André, Van Anh Nguyen, Heidi A Neubauer, Roman Fleck, Olaf Merkel, Marco Herling, Ellen Heitzer, Patrick T Gunning, Lukas Kenner, Richard Moriggl, Peter Wolf
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Springer Nature 2022-11-01
Rangatū:EMBO Molecular Medicine
Ngā marau:
lymphoma
STAT3
STAT5
targeting
T‐cell
Urunga tuihono:https://doi.org/10.15252/emmm.202115200
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