Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models
Abstract Complement is involved in developmental synaptic pruning and pathological synapse loss in Alzheimer’s disease. It is posited that C1 binding initiates complement activation on synapses; C3 fragments then tag them for microglial phagocytosis. However, the precise mechanisms of complement-med...
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| Asıl Yazarlar: | , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
BMC
2022-07-01
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| Seri Bilgileri: | Acta Neuropathologica Communications |
| Konular: | |
| Online Erişim: | https://doi.org/10.1186/s40478-022-01404-w |
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