Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models

Abstract Complement is involved in developmental synaptic pruning and pathological synapse loss in Alzheimer’s disease. It is posited that C1 binding initiates complement activation on synapses; C3 fragments then tag them for microglial phagocytosis. However, the precise mechanisms of complement-med...

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Bibliografiske detaljer

Principais autores:	Sarah M. Carpanini, Megan Torvell, Ryan J. Bevan, Robert A. J. Byrne, Nikoleta Daskoulidou, Takashi Saito, Takaomi C. Saido, Philip R. Taylor, Timothy R. Hughes, Wioleta M. Zelek, B. Paul Morgan
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2022-07-01
Serier:	Acta Neuropathologica Communications
Fag:	Complement Membrane attack complex Synapse loss Alzheimer’s disease
Online adgang:	https://doi.org/10.1186/s40478-022-01404-w
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