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Integrative analysis of proteomics and metabolomics reveals amino acid metabolism disorder in adriamycin-resistant acute myeloid leukemia cells

Abstract Acute myeloid leukemia (AML) is a complex and aggressive hematopoietic malignancy. Clinically, adriamycin is an important therapeutic drug. However, drug resistance often leads to refractory or relapse of patients after anthracycline-based treatment, and the prognosis is poor. Despite exten...

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Principais autores: Cong Li, Xue Liang, Siqi Gong, Mengmeng Fan, Yanghua Tian, Qiang Hong, Zhimin Zhai
格式: Artigo
語言:Inglês
出版: Nature Portfolio 2026-01-01
叢編:Scientific Reports
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在線閱讀:https://doi.org/10.1038/s41598-026-35675-3
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