Two-Sample Mendelian Randomization detects bidirectional causality between gut microbiota and celiac disease in individuals with high genetic risk

BackgroundCeliac Disease (CeD) is an autoimmune disorder triggered by gluten intake in genetically susceptible individuals. Highest risk individuals are homozygous for the Human Leucocyte Antigen (HLA) DQ2.5 haplotype or DQ2.5/DQ2.2 heterozygous. Both the HLA-DQ2-positive high genetic risk individua...

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Autors principals:	Bárbara P. González-García, Sergi Marí, Ariadna Cilleros-Portet, Alba Hernangomez-Laderas, Nora Fernandez-Jimenez, Iraia García-Santisteban, Jose Ramon Bilbao
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-06-01
Col·lecció:	Frontiers in Immunology
Matèries:	Mendelian randomization celiac disease HLA-DQ2 gut microbiota bidirectional causality
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1082862/full
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