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Two-Sample Mendelian Randomization detects bidirectional causality between gut microbiota and celiac disease in individuals with high genetic risk

BackgroundCeliac Disease (CeD) is an autoimmune disorder triggered by gluten intake in genetically susceptible individuals. Highest risk individuals are homozygous for the Human Leucocyte Antigen (HLA) DQ2.5 haplotype or DQ2.5/DQ2.2 heterozygous. Both the HLA-DQ2-positive high genetic risk individua...

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Kaydedildi:
Asıl Yazarlar: Bárbara P. González-García, Sergi Marí, Ariadna Cilleros-Portet, Alba Hernangomez-Laderas, Nora Fernandez-Jimenez, Iraia García-Santisteban, Jose Ramon Bilbao
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2023-06-01
Seri Bilgileri:Frontiers in Immunology
Konular:
Mendelian randomization
celiac disease
HLA-DQ2
gut microbiota
bidirectional causality
Online Erişim:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1082862/full
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