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Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111

For highly pathogenic viruses, reporter assays that can be rapidly performed are critically needed to identify potentially functional mutations for further study under maximal containment (e.g., biosafety level 4 [BSL-4]). The Ebola virus nucleoprotein (NP) plays multiple essential roles during the...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Aaron E. Lin, William E. Diehl, Yingyun Cai, Courtney L. Finch, Chidiebere Akusobi, Robert N. Kirchdoerfer, Laura Bollinger, Stephen F. Schaffner, Elizabeth A. Brown, Erica Ollmann Saphire, Kristian G. Andersen, Jens H. Kuhn, Jeremy Luban, Pardis C. Sabeti
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-01-01
Schriftenreihe:Viruses
Schlagworte:
ebola virus
nucleoprotein
budding
oligomerization
reporter assays
viral evolution
Online-Zugang:https://www.mdpi.com/1999-4915/12/1/105
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