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SUMOylation of FOXP1 regulates transcriptional repression via CtBP1 to drive dendritic morphogenesis

Abstract Forkhead Box P (FOXP) transcriptional repressors play a major role in brain development and their dysfunction leads to human cognitive disorders. However, little is known about how the activity of these proteins is regulated. Here, we show that FOXP1 SUMOylation at lysine 670 is required fo...

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Hlavní autoři: Daniel L. Rocca, Kevin A. Wilkinson, Jeremy M. Henley
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2017-04-01
Edice:Scientific Reports
On-line přístup:https://doi.org/10.1038/s41598-017-00707-6
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