MTHFD2 marks pemetrexed resistance in pulmonary adenocarcinoma with EGFR wild type

Abstract Purpose Lung cancer is the leading cause of cancer-related deaths worldwide. Patients with an amplification of the MTHFD2 gene have a particularly poor prognosis. MTHFD2 signaling has been associated with migration, metastasis, and proliferation of lung cancer cells mediated through ERK sig...

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Detalhes bibliográficos

Principais autores:	Sha Yao, Omar Elakad, Xiang Hui Yang, Adnan Raza Altaf, Wen Tao Yu, Hanibal Bohnenberger, Luo Gen Peng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer 2025-04-01
Colecção:	Discover Oncology
Assuntos:	MTHFD2 EGFR Pemetrexed Lung adenocarcinoma Chemoresistance
Acesso em linha:	https://doi.org/10.1007/s12672-025-02355-z
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