Genetic analysis of single-minded 1 gene in early-onset severely obese children and adolescents.

<h4>Background</h4>Inactivating mutations of the hypothalamic transcription factor singleminded1 (SIM1) have been shown as a cause of early-onset severe obesity. However, to date, the contribution of SIM1 mutations to the obesity phenotype has only been studied in a few populations. In this study, w...

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Main Authors:	Daniela Stanikova, Marek Buzga, Patrik Krumpolec, Martina Skopkova, Martina Surova, Barbara Ukropcova, Lubica Ticha, Miroslava Petrasova, Dominika Gabcova, Miroslava Huckova, Lucie Piskorova, Jan Bozensky, Marian Mokan, Jozef Ukropec, Ivona Zavacka, Iwar Klimes, Juraj Stanik, Daniela Gasperikova
Format:	Artigo
Language:	Inglês
Published:	Public Library of Science (PLoS) 2017-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0177222
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