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HIIT-induced lactate/GPR81 signaling with dual branches converging on ERK1/2 contributes to hippocampal synaptic remodeling and memory improvement

The remodeling of synapses in the hippocampus is intricately linked to processes of learning and memory. Research indicates that high-intensity interval training (HIIT) enhances cognitive functions reliant on the hippocampus in mice, although the specific receptor-mediated molecular pathways involve...

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Huvudupphov: Xuepeng Bian, Qinghui Shang, Lutao Zhu, Jun Liu, Min Wu, Jingjing Li, Shujie Lou
Materialtyp: Artigo
Språk:Inglês
Utgiven: Frontiers Media S.A. 2026-01-01
Serie:Frontiers in Cell and Developmental Biology
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Länkar:https://www.frontiersin.org/articles/10.3389/fcell.2026.1699042/full
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