PLCε regulates podocyte differentiation and TGF-β1 responses via alteration of SMAD2/SMAD3 ratio

Abstract Background Amongst genetic causes of nephrotic syndrome (NS), mutations in the PLCΕ1 gene have been described in patients with early onset NS and diffuse mesangial sclerosis (DMS). However, little is known about how these mutations alter podocyte biology although a role in podocyte differen...

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Hlavní autoři:	Carl J May, Sarah E Hunter, Agnieszka Bierzynska, Lan Ni, Katherine R Bull, Aneesha Bhandari, Gavin I Welsh, Moin A Saleem
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-05-01
Edice:	Cell Communication and Signaling
Témata:	TGF-β1 signaling PLCε Podocyte injury Proteinuria Glomerular disease Cell communication
On-line přístup:	https://doi.org/10.1186/s12964-026-02867-3
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