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PLCε regulates podocyte differentiation and TGF-β1 responses via alteration of SMAD2/SMAD3 ratio

Abstract Background Amongst genetic causes of nephrotic syndrome (NS), mutations in the PLCΕ1 gene have been described in patients with early onset NS and diffuse mesangial sclerosis (DMS). However, little is known about how these mutations alter podocyte biology although a role in podocyte differen...

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Kaydedildi:
Asıl Yazarlar: Carl J May, Sarah E Hunter, Agnieszka Bierzynska, Lan Ni, Katherine R Bull, Aneesha Bhandari, Gavin I Welsh, Moin A Saleem
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2026-05-01
Seri Bilgileri:Cell Communication and Signaling
Konular:
TGF-β1 signaling
PLCε
Podocyte injury
Proteinuria
Glomerular disease
Cell communication
Online Erişim:https://doi.org/10.1186/s12964-026-02867-3
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