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Rapamycin Enhances Mitophagy and Attenuates Apoptosis After Spinal Ischemia-Reperfusion Injury

The spinal cord is extremely vulnerable to ischemia-reperfusion (I/R) injury, and the mitochondrion is the most crucial interventional target. Rapamycin can promote autophagy and exert neuroprotective effects in several diseases of the central nervous system. However, the impact of rapamycin via mod...

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Principais autores: Qiang Li, Shane Gao, Zhanrong Kang, Meiyan Zhang, Xin Zhao, Yu Zhai, Jianming Huang, Guo-Yuan Yang, Wanju Sun, Jian Wang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-12-01
Serier:Frontiers in Neuroscience
Fag:
apoptosis
mitophagy
ischemia-reperfusion injury
rapamycin
spinal cord
Online adgang:https://www.frontiersin.org/article/10.3389/fnins.2018.00865/full
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