Quantification of plasma tau species containing the proline-rich region as a biomarker in Alzheimer’s disease

Abstract Tau-based blood biomarkers are increasingly recognised as important for the diagnosis of Alzheimer’s disease (AD). More than 60 proteolytic cleavage sites of tau have been identified, and current assays may miss critical information from some of the smaller protein fragments. By capturing a...

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Detalhes bibliográficos

Principais autores:	Mohammad Arastoo, Lewis K. Penny, Richard Lofthouse, Aaron Hitchcock, Anna Moelders, Sona Szalma, Andrew Porter, Soumya Palliyil, Charles R. Harrington, Claude M. Wischik
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-11-01
Colecção:	Scientific Reports
Assuntos:	Alzheimer’s disease Tauopathy Tau protein Tau fragments Polyclonal antibody Biomarker
Acesso em linha:	https://doi.org/10.1038/s41598-025-25864-x
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