Integrating DNA and RNA sequencing for enhanced pathogen detection in respiratory infections

Abstract Background The clinical value of shotgun metagenomic next-generation sequencing (mNGS) in improving the detection rates of respiratory pathogens is well-established. However, mNGS is complex and expensive. This study designed and evaluated the performance of targeted NGS (tNGS) in diagnosin...

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Главные авторы:	Dejian Gu, Jie Liu, Jiaping Wang, Yuting Yi, Yuxing Chu, Rui Gao, Hao Liu, Jun She, Binghuai Lu
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2025-03-01
Серии:	Journal of Translational Medicine
Предметы:	Target NGS test Capture probe enrichment Respiratory tract infection mNGS tNGS DNA and RNA sequencing
Online-ссылка:	https://doi.org/10.1186/s12967-025-06342-4
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