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Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics

Abstract FLT3-mutated acute myeloid leukemia (AML) remains difficult to treat due to frequent resistance to FLT3 inhibitors like midostaurin. In this study, we observed a progenitor-like CD38+CD45RA+ leukemic cell population that may be associated with midostaurin resistance. Midostaurin-resistant c...

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I tiakina i:
Ngā kaituhi matua: Nona Struyf, Henrik Gezelius, Anders Lundmark, Chiara Barizza, Hidde Ploeger, Lucia Rico Pizarro, Mattias Vesterlund, Georgios Mermelekas, Albin Österroos, Anna Bohlin, Sofia Bengtzén, Kerstin Hamberg Levedahl, Rozbeh Jafari, Lukas M. Orre, Janne Lehtiö, Päivi Östling, Brinton Seashore-Ludlow, Jessica Nordlund, Sören Lehmann, Olli Kallioniemi, Tom Erkers
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2026-03-01
Rangatū:npj Precision Oncology
Urunga tuihono:https://doi.org/10.1038/s41698-026-01363-8
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