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Glymphatic influx and clearance are perturbed in Huntington’s disease

The accumulation of mutant huntingtin protein aggregates in neurons is a pathological hallmark of Huntington’s disease (HD). The glymphatic system, a brain-wide perivascular network, facilitates the exchange of interstitial fluid and cerebrospinal fluid (CSF), supporting interstitial solute clearanc...

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Principais autores: Hongshuai Liu, Lin Chen, Chuangchuang Zhang, Chang Liu, Yuguo Li, Liam Cheng, Yuxiao Ouyang, Catherine Rutledge, John Anderson, Zhiliang Wei, Ziqin Zhang, Hanzhang Lu, Peter C.M. van Zijl, Jeffrey J. Iliff, Jiadi Xu, Wenzhen Duan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical investigation 2024-10-01
coleção:JCI Insight
Assuntos:
Neuroscience
Acesso em linha:https://doi.org/10.1172/jci.insight.172286
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