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FABP4 deactivates NF‐κB‐IL1α pathway by ubiquitinating ATPB in tumor‐associated macrophages and promotes neuroblastoma progression

Abstract Neuroblastoma (NB) is the most common and deadliest pediatric solid tumor. Targeting and reactivating tumor‐associated macrophages (TAMs) is necessary for reversing immune suppressive state and stimulating immune defense to exert tumoricidal function. However, studies on the function and re...

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Principais autores: Lei Miao, Zhenjian Zhuo, Jue Tang, Xiaomei Huang, Jiabin Liu, Hai‐Yun Wang, Huimin Xia, Jing He
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2021-04-01
Serier:Clinical and Translational Medicine
Fag:
FABP4
neuroblastoma
tumor environment
tumor‐associated macrophages
Online adgang:https://doi.org/10.1002/ctm2.395
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