Identification and Validation of VEGFR2 Kinase as a Target of Voacangine by a Systematic Combination of DARTS and MSI

Although natural products are an important source of drugs and drug leads, identification and validation of their target proteins have proven difficult. Here, we report the development of a systematic strategy for target identification and validation employing drug affinity responsive target stabili...

Descripció completa

Dades bibliogràfiques

Autors principals:	Yonghyo Kim, Yutaka Sugihara, Tae Young Kim, Sung Min Cho, Jin Young Kim, Ju Yeon Lee, Jong Shin Yoo, Doona Song, Gyoonhee Han, Melinda Rezeli, Charlotte Welinder, Roger Appelqvist, György Marko-Varga, Ho Jeong Kwon
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2020-03-01
Col·lecció:	Biomolecules
Matèries:	target identification target validation label-free method for drugs anti-angiogenesis mechanism of action receptor tyrosine kinases
Accés en línia:	https://www.mdpi.com/2218-273X/10/4/508
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!