TDP-43-mediated amyotrophic lateral sclerosis: new/hidden insights from Drosophila

Transactive response DNA-binding protein 43 (TDP-43) is a key factor in motor neurons and related neurodegenerative disorders, and the presence of cytoplasmic aggregates of TDP-43 is a major hallmark of diseases such amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). N...

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Autores principales:	Davide Colaianni, Nadia Ceccato, Pietro Antolini, Carmela Conte, Cristiano De Pittà, Fabian Feiguin, Gabriella M. Mazzotta
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2025-10-01
Colección:	Frontiers in Cell and Developmental Biology
Materias:	TDP-43 amyotrophic lateral sclerosis Drosophila melanogaster TBPH gene expression
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1677090/full
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