Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies

Recently, the TAR DNA-binding protein-43 (TDP-43) has been identified as a major constituent of nuclear and/or cytoplasmic ubiquitin-positive inclusions in patient with amyotrophic lateral sclerosis or frontotemporal lobar degeneration. Pathological proteins are abnormally hyperphosphorylated and pa...

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Hauptverfasser:	Laetitia Miguel, Thierry Frébourg, Dominique Campion, Magalie Lecourtois
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2011-02-01
Schriftenreihe:	Neurobiology of Disease
Schlagworte:	TDP-43 Drosophila Neurotoxicity Frontotemporal lobar degeneration Amyotrophic lateral sclerosis
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S0969996110003414
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