The single cell transcriptional landscape of esophageal adenocarcinoma and its modulation by neoadjuvant chemotherapy

Abstract Immune checkpoint blockade has recently proven effective in subsets of patients with esophageal adenocarcinoma (EAC) but little is known regarding the EAC immune microenvironment. We determined the single cell transcriptional profile of EAC in 8 patients who were treatment-naive (n = 4) or...

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Autores principales:	Wayne Croft, Richard P. T. Evans, Hayden Pearce, Mona Elshafie, Ewen A. Griffiths, Paul Moss
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2022-10-01
Colección:	Molecular Cancer
Materias:	Esophageal adenocarcinoma scRNA-Seq Regulatory T cell Cancer-associated fibroblast Plasmacytoid dendritic cell
Acceso en línea:	https://doi.org/10.1186/s12943-022-01666-x
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