Serine Palmitoyltransferase Gene Silencing Prevents Ceramide Accumulation and Insulin Resistance in Muscles in Mice Fed a High-Fat Diet

Skeletal muscles account for ~80% of insulin-stimulated glucose uptake and play a key role in lipid metabolism. Consumption of a high-fat diet (HFD) contributes to metabolic changes in muscles, including the development of insulin resistance. The studies carried out to date indicate that the accumul...

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Библиографические подробности

Главные авторы:	Monika Imierska, Piotr Zabielski, Kamila Roszczyc-Owsiejczuk, Emilia Sokołowska, Karolina Pogodzińska, Iwona Kojta, Agnieszka Błachnio-Zabielska
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2022-03-01
Серии:	Cells
Предметы:	insulin resistance ceramide skeletal muscle lipid metabolism gene silencing electroporation
Online-ссылка:	https://www.mdpi.com/2073-4409/11/7/1123
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