pH-Dependent Specificity of Papain-Like Cysteine Proteases Is Determined by S1 Binding Pocket

Papain-like cysteine proteases (PLCPs) are widely expressed enzymes, the main function of which is low-specific-protein turnover in the acidic conditions of lysosomes. Additionally, these proteases provide specific functions in other compartments such as cytosol, nucleus, and extracellular space. Th...

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Autores principales:	Anastasiia Petushkova, Arthur Zalevsky, Neonila Gorokhovets, Vladimir Makarov, Lyudmila Savvateeva, Marina Serebryakova, Andrey Golovin, Evgeni Zernii, Andrey Zamyatnin
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2022-11-01
Colección:	Biology and Life Sciences Forum
Materias:	papain-like cysteine proteases cysteine cathepsin enzymatic activity substrate specificity binding cleft
Acceso en línea:	https://www.mdpi.com/2673-9976/20/1/21
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