pH-Dependent Specificity of Papain-Like Cysteine Proteases Is Determined by S1 Binding Pocket

Papain-like cysteine proteases (PLCPs) are widely expressed enzymes, the main function of which is low-specific-protein turnover in the acidic conditions of lysosomes. Additionally, these proteases provide specific functions in other compartments such as cytosol, nucleus, and extracellular space. Th...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Anastasiia Petushkova, Arthur Zalevsky, Neonila Gorokhovets, Vladimir Makarov, Lyudmila Savvateeva, Marina Serebryakova, Andrey Golovin, Evgeni Zernii, Andrey Zamyatnin
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	MDPI AG 2022-11-01
Σειρά:	Biology and Life Sciences Forum
Θέματα:	papain-like cysteine proteases cysteine cathepsin enzymatic activity substrate specificity binding cleft
Διαθέσιμο Online:	https://www.mdpi.com/2673-9976/20/1/21
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