Combining mucosal microbiome and host multi-omics data shows prognostic potential in paediatric ulcerative colitis

Abstract Current first-line treatments of paediatric ulcerative colitis (UC) maintain a 6-month remission in only half of the patients. Relapse prediction at diagnosis could enable earlier introduction of immunosuppressants. We collected intestinal biopsies from 56 treatment-naïve children, combinin...

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Autori principali:	Maria Kulecka, Jill O’Sullivan, Rachel Fitzgerald, Ana Velikonja, Chloe E. Huseyin, Emilio J. Laserna-Mendieta, Patricia Ruiz-Limón, Julia Eckenberger, Miriam Vidal-Marín, Bastian-Alexander Truppel, Raminder Singh, Sandhia Naik, Nicholas M. Croft, Andriy Temko, Aldert Zomer, John MacSharry, Silvia Melgar, Protima Deb, Ian R. Sanderson, Marcus J. Claesson
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2025-08-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-025-62533-z
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