TREM2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimer's disease‐associated H157Y variant

Abstract We have characterised the proteolytic cleavage events responsible for the shedding of triggering receptor expressed on myeloid cells 2 (TREM2) from primary cultures of human macrophages, murine microglia and TREM2‐expressing human embryonic kidney (HEK293) cells. In all cell types, a solubl...

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Bibliografische Detailangaben

Hauptverfasser:	Peter Thornton, Jean Sevalle, Michael J Deery, Graham Fraser, Ye Zhou, Sara Ståhl, Elske H Franssen, Roger B Dodd, Seema Qamar, Beatriz Gomez Perez‐Nievas, Louise SC Nicol, Susanna Eketjäll, Jefferson Revell, Clare Jones, Andrew Billinton, Peter H St George‐Hyslop, Iain Chessell, Damian C Crowther
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer Nature 2017-08-01
Schriftenreihe:	EMBO Molecular Medicine
Schlagworte:	genetic risk microglia neurodegeneration neuroinflammation
Online-Zugang:	https://doi.org/10.15252/emmm.201707673
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