Human colonic EVs induce murine enteric neuroplasticity via the lncRNA GAS5/miR-23/NMDA NR2B axis

Postinfectious, diarrhea-predominant, irritable bowel syndrome (PI-IBS-D) is difficult to treat owing to its unknown pathophysiology. Extracellular vesicles (EVs) derived from human colon tissue and long noncoding RNAs (lncRNAs), such as growth arrest–specific 5 (GAS5), may play key roles in the pat...

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Principais autores:	QiQi Zhou, Liuqing Yang, Zachary T. Verne, Benjamin B. Zhang, Jeremy Z. Fields, Amber T. Thacker, G. Nicholas Verne
格式:	Artigo
語言:	Inglês
出版:	American Society for Clinical investigation 2025-03-01
叢編:	JCI Insight
主題:	Gastroenterology
在線閱讀:	https://doi.org/10.1172/jci.insight.178631
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