Predicting longitudinal basal forebrain volume in the Alzheimer’s disease spectrum: the role of sex and ApoE epsilon 4 genotype

IntroductionImaging studies showed early atrophy of the cholinergic basal forebrain (BF) already at prodromal stages of sporadic Alzheimer’s disease (AD). Women and carriers of the ApoE epsilon 4 (ApoE ε4) allele are more likely to develop the disease; however, the underlying mechanisms are still un...

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Autori principali:	Alice Grazia, Fedor Levin, Frank Jessen, Michael Wagner, Oliver Peters, Josef Priller, Anja Schneider, Jens Wiltfang, Emrah Düzel, Katharina Buerger, Robert Perneczky, Christoph Laske, Annika Spottke, Alfredo Ramirez, Stefan J. Teipel
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-02-01
Serie:	Frontiers in Neuroscience
Soggetti:	APOE ε4 basal forebrain hippocampus homozygotes sex-differences
Accesso online:	https://www.frontiersin.org/articles/10.3389/fnins.2026.1730947/full
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