Predicting longitudinal basal forebrain volume in the Alzheimer’s disease spectrum: the role of sex and ApoE epsilon 4 genotype

IntroductionImaging studies showed early atrophy of the cholinergic basal forebrain (BF) already at prodromal stages of sporadic Alzheimer’s disease (AD). Women and carriers of the ApoE epsilon 4 (ApoE ε4) allele are more likely to develop the disease; however, the underlying mechanisms are still un...

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Detalhes bibliográficos

Principais autores:	Alice Grazia, Fedor Levin, Frank Jessen, Michael Wagner, Oliver Peters, Josef Priller, Anja Schneider, Jens Wiltfang, Emrah Düzel, Katharina Buerger, Robert Perneczky, Christoph Laske, Annika Spottke, Alfredo Ramirez, Stefan J. Teipel
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-02-01
coleção:	Frontiers in Neuroscience
Assuntos:	APOE ε4 basal forebrain hippocampus homozygotes sex-differences
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnins.2026.1730947/full
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