Lactate treatment improves brain biochemistry and cognitive function in transgenic Alzheimer’s and wild-type mice

Abstract Lactate, a well-known metabolite and signalling molecule, holds therapeutic potential for neurodegenerative diseases. Here, we investigated the effects of chronic lactate treatment on cognition and molecular biomarkers in the 5XFAD mouse model of Alzheimer’s disease (AD) and in wild-type (W...

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Detalles Bibliográficos

Principais autores:	Imen Belhaj, Ingrid Åmellem, Can H. Tartanoglu, Hanne M. Weidemann, Evan M. Vallenari, Mingyi Yang, Farrukh A. Chaudhry, Magnar Bjørås, Jon Storm-Mathisen, Linda Hildegard Bergersen
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2026-04-01
Series:	Scientific Reports
Assuntos:	Lactate Alzheimer’s disease 5XFAD Glutamate receptors Growth factors Neuroinflammation
Acceso en liña:	https://doi.org/10.1038/s41598-026-48154-6
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