Lactate treatment improves brain biochemistry and cognitive function in transgenic Alzheimer’s and wild-type mice

Abstract Lactate, a well-known metabolite and signalling molecule, holds therapeutic potential for neurodegenerative diseases. Here, we investigated the effects of chronic lactate treatment on cognition and molecular biomarkers in the 5XFAD mouse model of Alzheimer’s disease (AD) and in wild-type (W...

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Hlavní autoři:	Imen Belhaj, Ingrid Åmellem, Can H. Tartanoglu, Hanne M. Weidemann, Evan M. Vallenari, Mingyi Yang, Farrukh A. Chaudhry, Magnar Bjørås, Jon Storm-Mathisen, Linda Hildegard Bergersen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-04-01
Edice:	Scientific Reports
Témata:	Lactate Alzheimer’s disease 5XFAD Glutamate receptors Growth factors Neuroinflammation
On-line přístup:	https://doi.org/10.1038/s41598-026-48154-6
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