BACE1 in the retina: a sensitive biomarker for monitoring early pathological changes in Alzheimer′s disease

Because of a lack of sensitive biomarkers, the diagnosis of Alzheimer′s disease (AD) cannot be made prior to symptom manifestation. Therefore, it is crucial to identify novel biomarkers for the presymptomatic diagnosis of AD. While brain lesions are a major feature of AD, retinal pathological change...

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Autors principals:	Lan Li, Jia Luo, Dan Chen, Jian-bin Tong, Le-ping Zeng, Yan-qun Cao, Jian Xiang, Xue-gang Luo, Jing-ming Shi, Hui Wang, Ju-fang Huang
Format:	Artigo
Idioma:	Inglês
Publicat:	Wolters Kluwer Medknow Publications 2016-01-01
Col·lecció:	Neural Regeneration Research
Matèries:	nerve regeneration; neurodegenerative disease; Alzheimer′s disease; retina; amyloid-β; β-site amyloid precursor protein cleaving enzyme 1; APP/PS-1 transgenic mouse; neural regeneration
Accés en línia:	http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=3;spage=447;epage=453;aulast=
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