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New Adamantane-Containing Edaravone Conjugates as Potential Neuroprotective Agents for ALS Treatments

Currently, there are no effective drugs for the treatment of amyotrophic lateral sclerosis (ALS). Only two drugs—edaravone and riluzole—have been approved, but they have very limited efficacy. The aim of this work was to modify the structural core of the Edaravone—phenylpyrazolone moiety and combine...

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Principais autores: Maria A. Lapshina, Elena F. Shevtsova, Vladimir V. Grigoriev, Aleksey Yu. Aksinenko, Aleksey A. Ustyugov, Daniil A. Steinberg, Grigoriy V. Maleev, Elena S. Dubrovskaya, Tatiana V. Goreva, Tatiana A. Epishina, Vladimir L. Zamoyski, Galina F. Makhaeva, Vladimir P. Fisenko, Ivan M. Veselov, Daria V. Vinogradova, Sergey O. Bachurin
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-11-01
Serier:Molecules
Fag:
amyotrophic lateral sclerosis (ALS)
edaravone
aminoadamantanes
lipid peroxidation
mitochondria
FUS protein
Online adgang:https://www.mdpi.com/1420-3049/28/22/7567
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