Intracellular peroxynitrite perturbs redox balance, bioenergetics, and Fe–S cluster homeostasis in Mycobacterium tuberculosis

The ability of Mycobacterium tuberculosis (Mtb) to tolerate nitric oxide (•NO) and superoxide (O2•−) produced by phagocytes contributes to its success as a human pathogen. Recombination of •NO and O2•− generates peroxynitrite (ONOO−), a potent oxidant produced inside activated macrophages causing le...

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Detalhes bibliográficos

Principais autores:	Arshiya Dewan, Charu Jain, Mayashree Das, Ashutosh Tripathi, Ajay Kumar Sharma, Harshit Singh, Nitish Malhotra, Aswin Sai Narain Seshasayee, Harinath Chakrapani, Amit Singh
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-09-01
coleção:	Redox Biology
Assuntos:	Peroxynitrite Tuberculosis Fe–S clusters Redox Bioenergetics
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213231724002635
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