Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease

CARD11 functions as a key signaling scaffold that controls antigen-induced lymphocyte activation during the adaptive immune response. Somatic mutations in CARD11 are frequently found in Non-Hodgkin lymphoma, and at least three classes of germline CARD11 mutations have been described as the basis for...

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Detalhes bibliográficos

Principais autores:	Jacquelyn R. Bedsaul, Nicole M. Carter, Katelynn E. Deibel, Shelby M. Hutcherson, Tyler A. Jones, Zhaoquan Wang, Chao Yang, Yong-Kang Yang, Joel L. Pomerantz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-09-01
coleção:	Frontiers in Immunology
Assuntos:	CARD11 Bcl10 MALT1 primary immunodeficiency lymphoma T cell receptor
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02105/full
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