Potentiation of noncanonical NF-κB signaling and marginal zone B cell expansion by CARD11-mediated regulation of p100 processing

Summary: The signaling scaffold CARD11 is critical for adaptive immunity and antigen receptor signaling to canonical nuclear factor κB (NF-κB), mTOR, JNK, and AKT. Oncogenic gain-of-function (GoF) CARD11 mutants, implicated in a variety of lymphomas, bypass regulation and signal constitutively. In m...

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Váldodahkkit:	Anushka Ghosh, Tyler A. Jones, Sophie Mackinnon, Shelby M. Hutcherson, Julia M. Tritapoe, Piyusha Mongia, Neha Shah, Emma M. Mehlhop, Nicole M. Carter, Joel L. Pomerantz
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Elsevier 2025-12-01
Ráidu:	Cell Reports
Fáttát:	CP: immunology CP: cancer
Liŋkkat:	http://www.sciencedirect.com/science/article/pii/S2211124725013889
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