Bruceine E, a natural quassinoid from Brucea javanica, inhibits PARthanatos via targeting PARP1 in ischemic stroke

Ischemic stroke currently lacks evidence-based neuroprotective agents, primarily due to the challenge of timely intervention, which often occurs after the onset of irreversible neuronal damage. To address this, this study investigates the PARthanatos pathway, a form of regulated cell death triggered...

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Detalhes bibliográficos

Principais autores:	Chang Wei, Chun-ze Zhai, Chang-ling Yue, Yi-zhe Wang, Yin Cao, Qian-wen Yang, Zhao-huan Zhang, Xiao-hui Xu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-06-01
coleção:	Frontiers in Pharmacology
Assuntos:	bruceine E ischemic stroke PARP1 inhibitor parthanatos traditional Chinese medicine monomer library
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1843673/full
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