Bruceine E, a natural quassinoid from Brucea javanica, inhibits PARthanatos via targeting PARP1 in ischemic stroke

Ischemic stroke currently lacks evidence-based neuroprotective agents, primarily due to the challenge of timely intervention, which often occurs after the onset of irreversible neuronal damage. To address this, this study investigates the PARthanatos pathway, a form of regulated cell death triggered...

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Principais autores:	Chang Wei, Chun-ze Zhai, Chang-ling Yue, Yi-zhe Wang, Yin Cao, Qian-wen Yang, Zhao-huan Zhang, Xiao-hui Xu
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2026-06-01
סדרה:	Frontiers in Pharmacology
נושאים:	bruceine E ischemic stroke PARP1 inhibitor parthanatos traditional Chinese medicine monomer library
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1843673/full
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