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Modulating CAR-T cell exhaustion and fitness in acute myeloid leukemia: mechanistic metabolic and microenvironmental strategies

Chimeric antigen receptor (CAR) T-cell therapy has achieved transformative outcomes in B-cell malignancies but remains limited in acute myeloid leukemia (AML), where antigenic heterogeneity, a suppressive myeloid-driven microenvironment, and a metabolically restrictive bone marrow niche collectively...

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Hovedforfatter: Erden Atilla
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-06-01
Serier:Frontiers in Immunology
Fag:
AML
CAR T-cell engineering
CAR T-cell exhaustion
epigenetic regulation
metabolic fitness
microenvironment
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1863485/full
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