Modulating CAR-T cell exhaustion and fitness in acute myeloid leukemia: mechanistic metabolic and microenvironmental strategies

Chimeric antigen receptor (CAR) T-cell therapy has achieved transformative outcomes in B-cell malignancies but remains limited in acute myeloid leukemia (AML), where antigenic heterogeneity, a suppressive myeloid-driven microenvironment, and a metabolically restrictive bone marrow niche collectively...

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Autore principale:	Erden Atilla
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-06-01
Serie:	Frontiers in Immunology
Soggetti:	AML CAR T-cell engineering CAR T-cell exhaustion epigenetic regulation metabolic fitness microenvironment
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1863485/full
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