Codon pair optimization (CPO): a software tool for synthetic gene design based on codon pair bias to improve the expression of recombinant proteins in Pichia pastoris

Abstract Background Codon optimization is a common method to improve protein expression levels in Pichia pastoris and the current strategy is to replace rare codons with preferred codons to match the codon usage bias. However, codon-pair contexts have a profound effect on translation efficiency by i...

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Detalhes bibliográficos

Principais autores:	Yide Huang, Ting Lin, Lingfang Lu, Fan Cai, Jie Lin, Yu′e Jiang, Yao Lin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-11-01
coleção:	Microbial Cell Factories
Assuntos:	Pichia pastoris Codon pair bias Codon pair optimization Synthetic gene design
Acesso em linha:	https://doi.org/10.1186/s12934-021-01696-y
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