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E3 ubiquitin ligases in bone homeostasis: from regulatory mechanisms to skeletal diseases and therapeutic targeting

E3 ubiquitin ligases are key determinants of substrate specificity within the ubiquitin–proteasome system and have emerged as important regulators of skeletal biology. Although traditionally classified into RING-, HECT-, and RBR-type families based on structural features, their roles in bone homeost...

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Hlavní autoři: Yutong Zhao, Nanjue Cao, Wenxiao Yang, Yuanfang Wang, Wei Wang
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2026-05-01
Edice:Frontiers in Cell and Developmental Biology
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On-line přístup:https://www.frontiersin.org/articles/10.3389/fcell.2026.1825526/full
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