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E3 ubiquitin ligases in bone homeostasis: from regulatory mechanisms to skeletal diseases and therapeutic targeting

E3 ubiquitin ligases are key determinants of substrate specificity within the ubiquitin–proteasome system and have emerged as important regulators of skeletal biology. Although traditionally classified into RING-, HECT-, and RBR-type families based on structural features, their roles in bone homeost...

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Bibliografiske detaljer
Principais autores: Yutong Zhao, Nanjue Cao, Wenxiao Yang, Yuanfang Wang, Wei Wang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-05-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
Online adgang:https://www.frontiersin.org/articles/10.3389/fcell.2026.1825526/full
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