LAG3 (LAG-3, CD223) DNA methylation correlates with LAG3 expression by tumor and immune cells, immune cell infiltration, and overall survival in clear cell renal cell carcinoma

Background Lymphocyte activating 3 (LAG3, LAG-3, CD223) is a promising target for immune checkpoint inhibition in clear cell renal cell carcinoma (KIRC). The aim of this study was to investigate the epigenetic regulation of LAG3 in KIRC by methylation.Methods We correlated quantitative LAG3 methylat...

Полное описание

Библиографические подробности

Главные авторы:	Dimo Dietrich, Niklas Klümper, Damian J Ralser, Emma Grace Bawden, Jenny Landsberg, Romina Zarbl, Glen Kristiansen, Marieta Toma, Manuel Ritter, Michael Hölzel, Jörg Ellinger
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMJ Publishing Group 2020-05-01
Серии:	Journal for ImmunoTherapy of Cancer
Online-ссылка:	https://jitc.bmj.com/content/8/1/e000552.full
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